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・ Polarization spectroscopy
・ Polarization-division multiplexing
・ Polarization-maintaining optical fiber
・ Polarized 3D system
・ Polarized light microscopy
・ Polar sine
・ Polar space
・ Polar Star (Decembrist journal)
・ Polar Star (novel)
・ Polar Star (song)
・ Polar Star Expeditions
・ Polar stratospheric cloud
・ Polar Studios
・ Polar Subglacial Basin
・ Polar Sun Spire
Polar surface area
・ Polar T3 syndrome
・ Polar Tankers, Inc. v. City of Valdez
・ Polar the Titanic Bear
・ Polar Times Glacier
・ Polar topology
・ Polar Towers
・ Polar Trappers
・ Polar vortex
・ Polar wander
・ Polar wind
・ Polar Wrocław
・ Polar X-plorer
・ Polar Zoo
・ Polar, Wisconsin


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Polar surface area : ウィキペディア英語版
Polar surface area

The polar surface area (PSA) of a molecule is defined as the surface sum over all polar atoms, primarily oxygen and nitrogen, also including their attached hydrogens.
PSA is a commonly used medicinal chemistry metric for the optimisation of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared tend to be poor at permeating cell membranes. For molecules to penetrate the blood–brain barrier (and thus act on receptors in the central nervous system), a PSA less than 90 angstroms squared is usually needed.
==See also==

* Lipinski's Rule of Five
* Biopharmaceutics Classification System
* Implicit solvation
* Cheminformatics
*
* Chemistry Development Kit
*
* JOELib

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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